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Effects of metformin on prostatic tissue of rats with metabolic syndrome and benign prostatic hyperplasia

To investigate the efficacy of insulin sensitizer on prostatic tissue in animal model with benign prostatic hyperplasia (BPH) secondary to metabolic syndrome (MetS).

Models were established by providing Sprague—Dawley rats with high fat diet (HFD) combined with metformin or not. All objects were killed 40 days later with prostatic tissue being removed, weighed before stained, as well as the expression level of insulin-like growth factor I (IGF-1) and receptor (IGF-1R) being measured, and the level of insulin resistance (IR) has also been evaluated.

Model has been successfully established. Level of prostatic hyperplasia and IR as well as IGF-1 and IGF-1R expressions in the blank and saline control subunits of HFD group was higher than that of normal diet group (P < 0.05). In the subunit of metformin, along with the suppression of IR, the level of prostatic hyperplasia and the expression of IGF-1 pathway have both decreased (P < 0.05).

MetS can promote the growth of prostate during the formation of central obesity and IR. IGF-1 pathway may have an important role in the induction of BPH following IR. The application of metformin can suppress the expression of IGF-1 and IGF-1R, thus preventing the promotive effect of IR on prostate tissue in animal model of MetS.

Congyun Xu, Yan Xu, Zhou Shen, Hangcheng Zhou, Jun Xiao, Tao Huang
Department of Urology, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Tech-nology of China, Hefei, China
Department of Pathology, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China
International Urology and Nephrology, April 2018, Volume 50, Issue 4, pp 611–617
DOI: https://doi.org/10.1159/000484697

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