Role of Jun amino-terminal kinase (JNK) in apoptosis of cavernosal tissue during acute phase after cavernosal nerve injury

Volume 20, Issue 1 (January 2018) 20, 50–55; 10.4103/aja.aja_10_17 Won Hoon Song1, Hwancheol Son2, Soo Woong Kim1, Jae-Seung Paick1, Min Chul Cho2 1 Department of Urology, Seoul National University, College of Medicine, Seoul 03080, Korea 2 Department of Urology, Seoul National University, Boramae Medical Center, Seoul 07061, Korea Date of Submission 29-Sep-2016 Date of Decision Continue reading…

Risk factors and the prognosis of sexual dysfunction in male patients with pituitary adenomas: a multivariate analysis

Wen-Jian-Long Zhou1, Shun-Chang Ma2, Min Zhao3, Chang Liu4, Xiu-Dong Guan1, Zhao-Shi Bao1, Gui-Jun Jia1, Wang Jia1 1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China 2 Department of Neurosurgery, Beijing Fuxing Hospital, Capital Medical University, Beijing 100045, China 3 Department of Neurosurgery, Peking University International Hospital, Beijing 102206, China 4 Department Continue reading…

Predictive value of FSH, testicular volume, and histopathological findings for the sperm retrieval rate of microdissection TESE in nonobstructive azoospermia: a meta-analysis

Hao Li1, 2, Li-Ping Chen1, 2, Jun Yang1, 2, Ming-Chao Li1, 2, Rui-Bao Chen1, 2, Ru-Zhu Lan1, 2, Shao-Gang Wang1, 2, Ji-Hong Liu1, 2, Tao Wang1, 2 1 Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2 Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong Continue reading…

Aldosterone induces inflammatory cytokines in penile corpus cavernosum by activating the NF-κB pathway

Fei Wu, Zu-Quan Xiong, Shan-Hua Mao, Ji-Meng Hu, Jian-Qing Wang, Hao-Wen Jiang, Qiang Ding Department of Urology, Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China Date of Submission 21-Nov-2016 Date of Decision 09-Jan-2017 Date of Acceptance 06-Feb-2017 Date of Web Publication 04-Apr-2017 Abstract Emerging evidence indicates that aldosterone and mineralocorticoid receptors (MRs) Continue reading…

MP89-10 CRITICAL ANALYSIS OF MEDICAL TREATMENT BEFORE SURGERY IN NON-OBSTRUTIVE AZOOSPERMIA: A SYSTEMATIC REVIEW

THIAGO NUNES, RICARDO SAADE CAMPINAS, Brazil EDSON BORGES SAO PAULO, Brazil DOI: http://dx.doi.org/10.1016/j.juro.2017.02.2808 INTRODUCTION AND OBJECTIVES Currently, treatment of men with nonobstructive azoospermia (NOA) is accomplished through assisted reproduction using testicular sperm retrieval techniques combined with in vitro fertilization (IVF) by intracytoplasmic sperm injection technique (ICSI). Among the sperm retrieval techniques, testicular microdissection (micro-TESE) is presenting Continue reading…

Anti-Mullerian Hormone-to-Testosterone Ratio is Predictive of Positive Sperm Retrieval in Men with Idiopathic Non-Obstructive Azoospermia

Massimo Alfano, Eugenio Ventimiglia, Irene Locatelli, Paolo Capogrosso, Walter Cazzaniga, Filippo Pederzoli, Nicola Frego, Rayan Matloob, Antonino Saccà, Luca Pagliardini, Paola Viganò, Pietro Zerbi, Manuela Nebuloni, Marina Pontillo, Francesco Montorsi & Andrea Salonia Scientific Reports 7, Article number: 17638 (2017) doi:10.1038/s41598-017-17420-z The lack of clinically-reliable biomarkers makes impossible to predict sperm retrieval outcomes at testicular Continue reading…

Survey of Reproductive Experiences and Outcomes of Cancer Survivors Who Stored Reproductive Material Before Treatment

K Hammarberg M Kirkman C Stern R I McLachlan G Clarke F Agresta D Gook L Rombauts B Vollenhoven J R W Fisher Human Reproduction, Volume 32, Issue 12, 1 December 2017, Pages 2423–2430, https://doi.org/10.1093/humrep/dex314 Published: 17 October 2017 STUDY QUESTION What are the reproductive experiences and outcomes of people who store reproductive material before Continue reading…

Sleep Problems are Associated with Development and Progression of Lower Urinary Tract Symptoms: Results from REDUCE

Brandee L. Branche, Lauren E. Howard, Daniel M. Moreira, Claus Roehrborn, Ramiro Castro-Santamaria, Gerald L. Andriole, Martin L. Hopp, Stephen J. Freedland DOI: http://dx.doi.org/10.1016/j.juro.2017.08.108 Purpose Although lower urinary tract symptoms and sleep problems often develop together, to our knowledge it is unknown whether sleep disturbances are linked to lower urinary tract symptoms development and progression. Continue reading…

Reasons for Seeking Clinical Care for Lower Urinary Tract Symptoms: A Mixed Methods Study

James W. Griffith, Emily E. Messersmith, Brenda W. Gillespie, Jonathan B. Wiseman, Kathryn E. Flynn, Ziya Kirkali, John W. Kusek, Tamara Bavendam, David Cella, Karl J. Kreder, Jasmine J. Nero, Maria E. Corona, Catherine S. Bradley, Kimberly S. Kenton, Brian T. Helfand†, Robert M. Merion, Kevin P. Weinfurt and the LURN Study Group DOI: http://dx.doi.org/10.1016/j.juro.2017.07.067 Continue reading…

The inflammatory microenvironment and microbiome in prostate cancer development

Karen S. Sfanos, Srinivasan Yegnasubramanian, William G. Nelson & Angelo M. De Marzo Nature Reviews Urology 15, 11–24 (2018) doi:10.1038/nrurol.2017.167 Published online: 31 October 2017 Chronic inflammation promotes the development of several types of solid cancers and might contribute to prostate carcinogenesis. This hypothesis partly originates in the frequent observation of inflammatory cells in the Continue reading…

MAEL promoter hypermethylation is associated with de-repression of LINE-1 in human hypospermatogenesis

Yu-Sheng Cheng Shi-Kae Wee Tsung-Yen Lin Yung-Ming Lin Human Reproduction, Volume 32, Issue 12, 1 December 2017, Pages 2373–2381, https://doi.org/10.1093/humrep/dex329 Published: 31 October 2017 STUDY QUESTION Does the hypermethylation of the maelstrom spermatogenic transposon silencer (MAEL) promoter and subsequent de-repression of transposable elements represent one of the causes of spermatogenic failure in infertile men? SUMMARY Continue reading…

Experiences of Uncertainty in Men With an Elevated PSA

Caitlin Biddle, MA, Alicia Brasel, MPH, Willie Underwood, III, MS, MPH, MD, Heather Orom, PhD First Published May 15, 2015 Abstract A significant proportion of men, ages 50 to 70 years, have, and continue to receive prostate specific antigen (PSA) tests to screen for prostate cancer (PCa). Approximately 70% of men with an elevated PSA Continue reading…

Rapid microfluidic sperm isolation from microtese samples in men with non-obstructive azoospermia

T. Jenkins, R. Samuel, A. Jafek, H. Feng, B. Gale, D.T. Carrell, J.M. Hotaling P-360 Tuesday, October 31, 2017 DOI: http://dx.doi.org/10.1016/j.fertnstert.2017.07.733 Objective To significantly improve efficiency of sperm recovery and decrease processing time of MicroTESE samples from men with non-obstructive azoospermia (NOA). Design We have developed and tested a microfluidic system consisting of two modules. Continue reading…

Clinical Evaluation of Urine Prostatic Exosomal Protein in the Diagnosis of Chronic Prostatitis

Li X. · Jiang T. · Liu F. · Shao X. · Xu Y. · Sheng W. · Sun W. Department of Urology, The First People’s Hospital of Taicang and Affiliated to Soochow University, Taicang, China Keywords: ProstateProstatitisProstasomeProstatic exosomal proteinBiological markers Urol Int 2018;100:112–118 https://doi.org/10.1159/000479188 Objective: To evaluate the clinical potential of urine prostatic exosomal Continue reading…

Distribution of Neuroendocrine Cells in the Transition Zone of the Prostate

Advances in Urology Volume 2017 (2017), Article ID 8541697, 7 pages https://doi.org/10.1155/2017/8541697 Yuki Kyoda, Koji Ichihara, Kohei Hashimoto, Ko Kobayashi, Fumimasa Fukuta, and Naoya Masumori Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan Received 11 November 2016; Revised 10 February 2017; Accepted 14 February 2017; Published 1 March 2017 Academic Editor: James Continue reading…

Comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia

S.J. Morin, C.R. Juneau, S.A. Neal, J.N. Landis, R.T. Scott Jr., J.M. Hotaling O-11 Monday, October 30, 2017 12:00 PM DOI: http://dx.doi.org/10.1016/j.fertnstert.2017.07.034 Objective Multiple studies have compared the outcomes of ICSI utilizing epididymal or testicular sperm for men with obstructive azoospermia (OA). However, the results are conflicting and the operative approach still largely depends on Continue reading…

MP81-04 LEYDIG STEM CELL ISOLATION AND DIFFERENTIATION FROM HUMAN TESTIS BIOPSIES: POTENTIAL MODALITY TO INCREASE SERUM TESTOSTERONE

HIMANSHU ARORA, Marilia Sanches Santos Rizzo Zutti, Bruno Nahar, Joshua M. Hare, Ranjith Ramasamy MIAMI, FL DOI: http://dx.doi.org/10.1016/j.juro.2017.02.2530 INTRODUCTION AND OBJECTIVES Impaired testosterone production as a result of Leydig cell loss or dysfunction can occur in men with testicular failure. Testis failure is typically seen in men with Klinefelter syndrome and in men undergoing high Continue reading…

Microsurgical varicocele repair induces spermatogenesis among men with non obstructive azoospermia: a 25 year experience

R. Flannigan, P.V. Bach, M. Goldstein P-536 Wednesday, November 1, 2017 DOI: http://dx.doi.org/10.1016/j.fertnstert.2017.07.918 Objective The objective of this study was to determine the proportion of non-obstructive azoospermic (NOA) men that develop sperm in their ejaculate following varicocele repair (VR) and pregnancy outcomes. Design Retrospective review of all NOA men that have undergone VR at a Continue reading…

Mean platelet volume, platelet distribution width and platelet count in erectile dysfunction: A systematic review and meta-analysis

Z.-J. Ren, P.-W. Ren, B. Yang, J. Liao, S.-Z. Liu, D.-L. Lu, X. Wei, L.-R. Liu, Q. Dong Department of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan, China Andrologia, Volume 49, Issue 10, December 2017, e12777 DOI: 10.1111/and.12777 http://onlinelibrary.wiley.com/doi/10.1111/and.12777/full Summary The aim of this study was to investigate the relationship Continue reading…

Office-based minimally invasive epididymal sperm aspiration (MIESA) for obstructive azoospermia (OA) results in high quality cryopreserved samples and excellent in vitro fertilization (IVF) outcomes

R.C. Owen, J.E. Gray, M.A. Fritz, C.F. Boylan, R.M. Coward P-521 Wednesday, November 1, 2017 DOI: http://dx.doi.org/10.1016/j.fertnstert.2017.07.903 Objective To evaluate early experience with a new office-based sperm retrieval technique for OA and to report procedural and IVF outcomes. Design Retrospective case series. Materials and Methods The MIESA is performed in the office with oral or Continue reading…

Patient-reported ejaculatory function and satisfaction in men with lower urinary tract symptoms/benign prostatic hyperplasia

Min Chul Cho1, Jung Kwon Kim2, Sang Hoon Song3, Sung Yong Cho1, Sang Wook Lee4, Soo Woong Kim2, Jae-Seung Paick2 1 Department of Urology, Seoul National University, Boramae Medical Center, Seoul 07061, Korea 2 Department of Urology, Seoul National University, College of Medicine, Seoul 03080, Korea 3 Department of Urology, Asan Medical Center, Seoul 05505, Continue reading…

Long-Term Testosterone Therapy Improves Urinary and Sexual Function, and Quality of Life in Men with Hypogonadism: Results from a Propensity Matched Subgroup of a Controlled Registry Study

Karim Sultan Haider, Ahmad Haider∗, Gheorghe Doros∗, Abdulmaged Traish The Journal of urology, ISSN: 1527-3792, Vol: 199, Issue: 1, Page: 257-265 Publication Year: 2017 DOI: http://dx.doi.org/10.1016/j.juro.2017.07.039 Purpose We investigated the effects of long-term testosterone therapy on urinary and sexual function, and quality of life in hypogonadal men. Materials and Methods We performed an observational, prospective, Continue reading…

Transcriptome-wide association study revealed two novel genes associated with nonobstructive azoospermia in a Chinese population

Tingting Jiang, M.D., Yuzhuo Wang, M.D., Meng Zhu, M.D., Yifeng Wang, M.D., Mingtao Huang, M.D., Guangfu Jin, Ph.D., Xuejiang Guo, Ph.D., Jiahao Sha, Ph.D., Juncheng Dai, Ph.D., Zhibin Hu, Ph.D. DOI: http://dx.doi.org/10.1016/j.fertnstert.2017.09.023 Objective To investigate the associations between genetically cis-regulated gene expression levels and nonobstructive azoospermia (NOA) susceptibility. Design Transcriptome-wide association study (TWAS). Setting Medical Continue reading…

Chlamydia trachomatis versus common uropathogens as a cause of chronic bacterial prostatitis: Is there any difference? Results of a prospective parallel-cohort study

Investig Clin Urol. 2017 Nov;58(6):460-467. English. Published online October 31, 2017. https://doi.org/10.4111/icu.2017.58.6.460 © The Korean Urological Association, 2017 Tommaso Cai,1 Francesca Pisano,2 Gabriella Nesi,3 Vittorio Magri,4 Paolo Verze,5 Gianpaolo Perletti,6 Paolo Gontero,2 Vincenzo Mirone,5 and Riccardo Bartoletti7 1Department of Urology, Santa Chiara Regional Hospital, Trento, Italy. 2Department of Urology, University of Turin, Turin, Italy. 3Division Continue reading…

Prediction model for obtaining spermatozoa with testicular sperm extraction in men with non-obstructive azoospermia

M. Cissen A.M. Meijerink K.W. D’Hauwers A. Meissner N. van der Weide M.H. Mochtar A.A. de Melker L. Ramos S. Repping D.D.M. Braat K. Fleischer M. van Wely Human Reproduction, Volume 31, Issue 9, 1 September 2016, Pages 1934–1941, https://doi.org/10.1093/humrep/dew147 Published: 19 August 2016 STUDY QUESTION Can an externally validated model, based on biological variables, Continue reading…

Altered brain networks in psychogenic erectile dysfunction: a resting-state fMRI study

J. Chen,Y. Chen,G. Chen,Y. Dai,Z. Yao,Q. Lu First published: 26 October 2017 DOI: 10.1111/andr.12411 Summary Various neuroimaging studies had identified changes of cerebral activity and structures during the processes of sexual arousal. The identified brain regions were also believed to regulate emotional and cognitive processes. Yet, little was known about the neural mechanisms underlying psychogenic Continue reading…

Testosterone Responders to Continuous Androgen Deprivation Therapy Show Considerable Variations in Testosterone Levels on Followup: Implications for Clinical Practice

Rashid K. Sayyid, Abdallah K. Sayyid, Zachary Klaassen, Kamel Fadaak, Hanan Goldberg, Thenappan Chandrasekar, Ardalanejaz Ahmad, Ricardo Leao, Nathan Perlis, Karen Chadwick, Robert J. Hamilton, Girish S. Kulkarni, Antonio Finelli, Alexandre R. Zlotta, Neil E. Fleshner DOI: http://dx.doi.org/10.1016/j.juro.2017.07.078 Purpose We determined whether men on continuous androgen deprivation therapy who achieve testosterone less than 0.7 nmol/l Continue reading…

Sperm freezing to address the risk of azoospermia on the day of ICSI

M. Montagut N. Gatimel S. Bourdet-Loubère M. Daudin L. Bujan R. Mieusset F. Isus J. Parinaud R. Leandri Human Reproduction, Volume 30, Issue 11, 1 November 2015, Pages 2486–2492, https://doi.org/10.1093/humrep/dev234 Published: 12 September 2015 STUDY QUESTION In which cases is freezing of ejaculated sperm indicated before ICSI? SUMMARY ANSWER Sperm freezing should be performed only Continue reading…

Outcome of microsurgical subinguinal varicocelectomy in men with nonobstructive azoospermia

M.M. Arafa, H. Elbardisi, A. Majzoub, S.S. Alsaid P-72 Tuesday, October 31, 2017 DOI: http://dx.doi.org/10.1016/j.fertnstert.2017.07.408 Objective This study aims to investigate the effect of microsurgical subinguinal varicocelectomy in nonobstructive azoospermic men with palpable varicocele and determine predictive parameters of outcome. Design Retrospective cohort study. Materials and Methods This was a retrospective review of data pooled Continue reading…

Y Chromosome Microdeletions in Infertile Men with Non-obstructive Azoospermia and Severe Oligozoospermia

Shin Young Kim,1 Hyun Jin Kim,1 Bom Yi Lee,1 So Yeon Park,1 Hyo Serk Lee,2 and Ju Tae Seo2,* 1- Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women’s Healthcare Center, Seoul, Korea 2- Department of Urology, Cheil General Hospital and Women’s Healthcare Center, Dankook University College of Medicine, Seoul, Korea *Corresponding Continue reading…

Clinical value of ultrasonographic (US) analysis of seminiferous tubules for predicting successful sperm retrieval in patients with non-obstructive azoospermia (NOA)

S. Nariyoshi, T. Sho, K. Nakano, K. Yamamoto, G. Sukegawa, Y. Tsuji P-523 Wednesday, November 1, 2017 DOI: http://dx.doi.org/10.1016/j.fertnstert.2017.07.905   Objective Microdissection testicular sperm extraction (micro-TESE) has become the gold standard technique for retrieving sperm in NOA. At present, however, there are no reliable predictors of the presence of testicular sperm in NOA patients. The Continue reading…

The Nonpalpable Testis: A Narrative Review

Courtney L. Shepard, Kate H. Kraft Department of Urology, University of Michigan, Ann Arbor, Michigan DOI: http://dx.doi.org/10.1016/j.juro.2017.04.079   Purpose While the nonpalpable testis represents a small portion of all cryptorchid testes, it remains a clinical challenge for pediatric urologists. Controversy exists surrounding the best evaluation and management of this entity. In this review we update Continue reading…

Effect of Preoperative Urodynamic Detrusor Underactivity on Transurethral Surgery for Benign Prostatic Hyperplasia: A Systematic Review and Meta-Analysis

Myong Kim, Chang Wook Jeong, Seung-June Oh Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea Department of Urology, Seoul National University College of Medicine, Seoul National University Hospital (CWJ, SJO), Seoul, Republic of Korea DOI: http://dx.doi.org/10.1016/j.juro.2017.07.079   Purpose We investigated the effect of preoperative urodynamic detrusor underactivity Continue reading…

Factor V Leiden is associated with increased sperm count

T E van Mens U N Joensen Z Bochdanovits A Takizawa J Peter N Jørgensen P B Szecsi J C M Meijers H Weiler E Rajpert-De Meyts S Repping S Middeldorp Human Reproduction, Volume 32, Issue 11, 1 November 2017, Pages 2332–2339, https://doi.org/10.1093/humrep/dex287 Published: 12 September 2017 STUDY QUESTION Is the thrombophilia mutation factor V Continue reading…

Chronic Prostate Inflammation is Associated with Severity and Progression of Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms and Risk of Acute Urinary Retention

J. Curtis Nickel, Claus G. Roehrborn, Ramiro Castro-Santamaria, Stephen J. Freedland, Daniel M. Moreira Department of Urology, Queen’s University, Kingston, Ontario, Canada Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas Department of Urology, Mayo Clinic, Rochester, Minnesota Global R&D Unit, GlaxoSmithKline, Inc., King of Prussia, Pennsylvania Division of Urology, Department of Surgery, Continue reading…

Changes in Adenosine Triphosphate and Nitric Oxide in the Urothelium of Patients with Benign Prostatic Hyperplasia and Detrusor Underactivity

Kang Jun Cho, Jun Sung Koh, Jinbong Choi, Joon Chul Kim Department of Urology, Bucheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea DOI: http://dx.doi.org/10.1016/j.juro.2017.06.080   Purpose We investigated changes in the levels of adenosine triphosphate and nitric oxide in the urothelium of men with detrusor underactivity and benign prostatic hyperplasia. Continue reading…

Taste receptor polymorphisms and male infertility

M Gentiluomo L Crifasi A Luddi D Locci R Barale P Piomboni D Campa Human Reproduction, Volume 32, Issue 11, 1 November 2017, Pages 2324–2331, https://doi.org/10.1093/humrep/dex305 Published: 12 October 2017   STUDY QUESTION Are polymorphisms of taste receptor genes associated with male infertility? SUMMARY ANSWER This study has showed the associations between three single nucleotide Continue reading…

MP17-03 INFLAMMATION-INDUCED PROSTATIC ENLARGEMENT AND PROLIFERATION OF PROSTATE EPITHELIAL CELLS IS REDUCED BY GROWTH HORMONE-RELEASING HORMONE (GHRH) ANTAGONISTS THROUGH THE INHIBITION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION

Petra Popovics, Andrew Schally, Luis Salgueiro, Krisztina Kovacs, Ferenc Rick Miami, FL DOI: http://dx.doi.org/10.1016/j.juro.2017.02.592 INTRODUCTION AND OBJECTIVES The pathogenesis of benign prostatic hyperplasia (BPH) has been associated with various factors including hormonal imbalance, inflammation-induced cell proliferation and epithelial-to-mesenchymal transition. We have previously demonstrated that prostatic GHRH and its receptors are upregulated in a rat testosterone-induced Continue reading…

MP43-18 DOES VARICOCELE REPAIR IMPROVE TOTAL MOTILE SPERM COUNT (TMSC) IN ADOLESCENTS? A PILOT STUDY

Mihir Shah Philadelphia, PA Julia Barthold, Li Xie, Ahmad Bani-Hani Wilmington, DE DOI: http://dx.doi.org/10.1016/j.juro.2016.02.227   INTRODUCTION AND OBJECTIVES In the absence of symptoms, the treatment of varicocele is aimed towards fertility preservation. While the current indication for varicocele repair in adolescent males is ipsilateral testicular hypotrophy, both total testicular volume and volume differential (TVDiff) correlate Continue reading…

PD68-12 STUDY TO ANALYSE THE FERTILITY POTENTIAL OF VARICOCELECTOMY IN NON-OBSTRUCTIVE AZOOSPERMIA (NOA), VIRTUAL AZOOSPERMIA (VA) AND SEVERE OLIGOSPERMIA (SO)

Ashwin Tamhankar Mumbai, India Ajit Sawant, Vijay Kulkarni, Prakash Pawar, Shankar Mundhe, Sunil Patil Mumbi, India DOI: http://dx.doi.org/10.1016/j.juro.2017.02.3140   INTRODUCTION AND OBJECTIVES Varicocele occurs in 35% and 75% of primary and secondary infertility. Azoospermia and SO occurs in 4.3% and 13.3% patients with varicocele. Primary objective was to analyse improvement in semen parameters after varicocelectomy Continue reading…

Predictive Factors for Sperm Recovery after Varicocelectomy in Men with Nonobstructive Azoospermia

Koji Shiraishi, Shintaro Oka, Hideyasu Matsuyama Department of Urology, Yamaguchi University School of Medicine, Yamaguchi, Japan DOI: http://dx.doi.org/10.1016/j.juro.2016.08.085   Purpose The ability of testicular histopathology to predict the success of microsurgical varicocelectomy in patients with nonobstructive azoospermia was investigated. We used a next generation sequencer to compare the transcriptomes of varicocelectomy responsive and nonresponsive testes Continue reading…

MP33-14 THE ROLE OF CHRONIC PROSTATIC INFLAMMATION IN PROSTATE CARCINOGENESIS: A RETROSPECTIVE FOLLOW-UP STUDY

Liwei Jia, Shawn Silver, Gregory MacLennan Cleveland, OH DOI: http://dx.doi.org/10.1016/j.juro.2017.02.1010 INTRODUCTION AND OBJECTIVES Chronic inflammation is a well-known contributor to several human cancers. The aim of this study was to investigate the role of chronic prostatic inflammation in prostatic carcinogenesis, with a specific focus on high grade cancers. METHODS A retrospective search was performed to Continue reading…

Semen quality impairment is associated with sexual dysfunction according to its severity

F. Lotti G. Corona G. Castellini E. Maseroli M.G. Fino M. Cozzolino M. Maggi Human Reproduction, Volume 31, Issue 12, 1 December 2016, Pages 2668–2680, https://doi.org/10.1093/humrep/dew246 Published: 17 November 2016 STUDY QUESTION Is sexual dysfunction associated with severity of semen quality impairment in men with couple infertility? SUMMARY ANSWER In males of infertile couples the Continue reading…

Effectiveness of highly purified urofollitropin treatment in patients with idiopathic azoospermia before testicular sperm extraction

Introduction Recent evidences demonstrated that male factor alone is responsible for about 30% cases of infertility. Human follicle-stimulating hormone (hFSH) has been introduced to increase sperm concentration, spermatogonial population, or both natural or assisted pregnancy rates (PRs) in oligozoospermic subjects with normal concentrations of gonadotropins. Methods Fifty infertile men affected by idiopathic azoospermia were enrolled Continue reading…

MP17-01 INFLAMMASOME ACTIVATION LEADS TO IL-18 EXPRESSION IN PROSTATIC INFLAMMATION ASSOCIATED WITH BPH

Pradeep Tyagi, Mahendra Kashyap, Jeffrey Gingrich, Zhou Wang, Naoki Yoshimura Pittsburgh, PA DOI: http://dx.doi.org/10.1016/j.juro.2017.02.590 INTRODUCTION AND OBJECTIVES Large clinical studies have implicated prostatic inflammation as a major player in the progression of benign prostatic hyperplasia (BPH). However, the molecular mechanisms that contribute to the inflammation in BPH remain unexplored. Animal studies on prostatic inflammation demonstrated Continue reading…

MP13-19 MEDIATORS OF PROSTATIC INFLAMMATION: SIMULTANEOUS MULTIPLEX ANALYSIS OF URINE AND SERUM SPECIMENS

Pradeep Tyagi, Mahendra Kashyap, Jeffrey Gingrich, Zhou Wang, Naoki Yoshimura Pittsburgh, PA DOI: http://dx.doi.org/10.1016/j.juro.2017.02.462 INTRODUCTION AND OBJECTIVES Discovery of serum biomarkers for benign prostatic hyperplasia (BPH) is strongly pursued by the MTOPSProstatic Samples Analysis (MPSA) Consortium and other groups in order to discriminate BPH-related pathologies, identify risk of progressive disease; and personalized management of BPH-related Continue reading…

MP07-17 ROLE OF OXIDATION REDUCTION POTENTIAL IN VARICOCELE ASSOCIATED MALE INFERTILITY

Mohamed Arafa, Haitham ElBardisi, Ahmad Majzoub, Sami AlSaid, Abdel Rahman Jaber, Kareim Khalafalla Doha, Qatar Siew May Wang, Ashok Agarwal Cleveland, OH DOI: http://dx.doi.org/10.1016/j.juro.2017.02.283 INTRODUCTION AND OBJECTIVES Patients with varicocele tend to have poor sperm quality and are at higher risk of being infertile. Although the pathophysiology of infertility in males with varicocele has been Continue reading…

Genomic fragmentation and extrachromosomal telomeric repeats impact assessment of telomere length in human spermatozoa: quantitative experiments and systematic review

P Kurjanowicz, S Moskovtsev, C Librach Human Reproduction, Volume 32, Issue 11, 1 November 2017, Pages 2170–2177, https://doi.org/10.1093/humrep/dex288 Published: 29 September 2017 STUDY QUESTION Can differences in DNA isolation alter assessment of sperm telomere length (spTL) and do they account for conflicting results in the literature on spTL and male fertility? SUMMARY ANSWER DNA isolation Continue reading…

Preconception urinary phthalate concentrations and sperm DNA methylation profiles among men undergoing IVF treatment: a cross-sectional study

Haotian Wu, Molly S Estill, Alexander Shershebnev, Alexander Suvorov, Stephen A Krawetz, Brian W Whitcomb, Holly Dinnie, Tayyab Rahil, Cynthia K Sites, J Richard Pilsner Human Reproduction, Volume 32, Issue 11, 1 November 2017, Pages 2159–2169, https://doi.org/10.1093/humrep/dex283 Published: 12 September 2017 STUDY QUESTION Are preconception phthalate and phthalate replacements associated with sperm differentially methylated regions Continue reading…

Cryopreservation of very low numbers of spermatozoa from male patients undergoing infertility treatment using agarose capsules

Shota Hatakeyama, Susumu Tokuoka, Hiroyuki Abe, Yasuyuki Araki, Yasuhisa Araki First Online: 01 March 2017 This study tried to cryopreserve low numbers of spermatozoa from men undergoing infertility treatments by inserting into agarose capsules. The capsules were transferred into a drop of cryoprotectant solution and injected 3–4 motile spermatozoa that were selected by the swim-up Continue reading…

Varicocele-induced male infertility – a mitochondrial disease

L. Samanta, A. Agarwal, R. Sharma, N. Swain, E.S. Sabanegh P-533 Wednesday, November 1, 2017 DOI: http://dx.doi.org/10.1016/j.fertnstert.2017.07.915 Objective Impaired respiratory chain, oxidative phosphorylation, mitochondrial protein import, alterations of the inner mitochondrial membrane composition and defects of mitochondrial dynamics are characteristics of mitochondrial disease. Our recently published proteomic data on comparative proteomic analysis of sperm proteins Continue reading…

Functional Variations in the NOS3 Gene Are Associated With Erectile Dysfunction Susceptibility, Age of Onset and Severity in a Han Chinese Population

Bo Yang, MD, Liangren Liu, MD, PhD, Zhufeng Peng, MD, PhD, Dongliang Lu, MD, Zhengju Ren, MD, Shengzuo Liu, MD, Xiling Yang, MD, Jian Liao, MD, Qiang Dong, MD, PhD, PhD Qiang Dong DOI: http://dx.doi.org/10.1016/j.jsxm.2017.02.003 Background Impaired function of endothelial nitric oxide synthase (eNOS) is involved in the pathologic processes of erectile dysfunction (ED), and Continue reading…

Erectile Dysfunction in Male Adults With Atopic Dermatitis and Psoriasis

Alexander Egeberg, Peter R. Hansen, MD, PhD, DMSc, Gunnar H. Gislason, MD, PhD, Lone Skov, MD, PhD, DMSc, Jacob P. Thyssen, MD, PhD, DMSc DOI: http://dx.doi.org/10.1016/j.jsxm.2016.12.233 Introduction Patients with psoriasis have increased risk of cardiovascular disease, but data on atopic dermatitis (AD) are less clear-cut. However, it is well-established that erectile dysfunction (ED) can serve Continue reading…

Use of Exogenous Testosterone for the Treatment of Male Factor Infertility: A Survey of Nigerian Doctors

Olufunmilade Akinfolarin Omisanjo,1 Stephen Odunayo Ikuerowo,1 Moruf Adekunle Abdulsalam,2 Sheriff Olabode Ajenifuja,2 and Khadijah Adebisi Shittu3 1Department of Surgery, Lagos State University College of Medicine and Teaching Hospital (LASUCOM/LASUTH), Ikeja, Lagos, Nigeria 2Department of Surgery, Lagos State University Teaching Hospital (LASUTH), Ikeja, Lagos, Nigeria 3Department of Obstetrics and Gynaecology, Lagos State University Teaching Hospital (LASUTH), Continue reading…

Microsurgically Assisted Inguinal Hernia Repair and Simultaneous Male Fertility Procedures: Rationale, Technique and Outcomes

Michael L. Schulster∗, Matthew R. Cohn, Bobby B. Najari∗,†, Marc Goldstein Department of Urology and Institute for Reproductive Medicine, Weill Cornell Medicine, New York, New York ∗Current address: Department of Urology, New York University Langone Medical Center, New York, New York. †Current address: Department of Population Health, New York University Langone Medical Center, New York, Continue reading…

Comprehensive Qualitative Assessment of Urethral Stricture Disease: Toward the Development of a Patient Centered Outcome Measure

Benjamin N. Breyer, Todd C. Edwards, Donald L. Patrick, Bryan B. Voelzke DOI: http://dx.doi.org/10.1016/j.juro.2017.05.077 Purpose The primary objective of this study was to report what patients considered to be the most important symptoms, functions and impacts of urethral stricture disease. Patient and physician perspectives were correlated. Materials and Methods Patients were involved at each step Continue reading…

Independent Predictors of Stricture Recurrence Following Urethroplasty for Isolated Bulbar Urethral Strictures

David Chapman, Adam Kinnaird, Keith Rourke Division of Urology, Department of Surgery, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada  DOI: http://dx.doi.org/10.1016/j.juro.2017.05.006 Purpose We evaluated preoperative risk factors associated with stricture recurrence in a large, homogenous series of bulbar urethroplasties. Materials and Methods We analyzed the records of 596 patients who underwent isolated bulbar Continue reading…

Evaluation of the diagnostic efficacy of strain elastography in infertile population with normal and abnormal semen parameters

Faruk Küçükdurmaz 1 , Mehmet Akif Sarıca 2 , Özcan Emre 2 , Murat Baykara 2 , Betül Kızıldağ 2 , Sefa Resim 1 1 Department of Urology, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, Turkey 2 Department of Radiology, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, Turkey Turk J Urol 2017; 43: Continue reading…

Molecular microdeletion analysis of infertile men with karyotypic Y chromosome abnormalities

Yuan Pan, Hong-guo Zhang, QI Xi, First Published August 23, 2017 Objectives To investigate azoospermic factor (AZF) microdeletions in infertile men from northeastern China with karyotypic Y chromosome abnormalities. Methods G-banding of metaphase chromosomes and karyotype analysis were performed in all infertile male patients. Genomic DNA was isolated and used to analyze classical AZF microdeletions Continue reading…

The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance—challenges and future research opportunities

Christopher L R Barratt Lars Björndahl Christopher J De Jonge Dolores J Lamb Francisco Osorio Martini Robert McLachlan Robert D Oates Sheryl van der Poel Bianca St John Mark Sigman … Show more Human Reproduction Update, Volume 23, Issue 6, 1 November 2017, Pages 660–680, https://doi.org/10.1093/humupd/dmx021 Published: 19 July 2017 BACKGROUND Herein, we describe the Continue reading…

Temporal trends in sperm count: a systematic review and meta-regression analysis

Hagai Levine Niels Jørgensen Anderson Martino-Andrade Jaime Mendiola Dan Weksler-Derri Irina Mindlis Rachel Pinotti Shanna H Swan Human Reproduction Update, Volume 23, Issue 6, 1 November 2017, Pages 646–659, https://doi.org/10.1093/humupd/dmx022 Published: 25 July 2017 BACKGROUND Reported declines in sperm counts remain controversial today and recent trends are unknown. A definitive meta-analysis is critical given the Continue reading…

Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies

Albert Salas-Huetos Mònica Bulló Jordi Salas-Salvadó Human Reproduction Update, Volume 23, Issue 4, 1 July 2017, Pages 371–389, https://doi.org/10.1093/humupd/dmx006 Published: 10 March 2017 BACKGROUND Infertility is a global public health issue, affecting 15% of all couples of reproductive age. Male factors, including decreased semen quality, are responsible for ~25% of these cases. The dietary pattern, Continue reading…

Prevalence of endocrine and genetic abnormalities in boys evaluated systematically for a disorder of sex development

R. Nixon V. Cerqueira A. Kyriakou A. Lucas-Herald J. McNeilly M. McMillan A.I. Purvis E.S. Tobias R. McGowan S.F. Ahmed Human Reproduction, Volume 32, Issue 10, 1 October 2017, Pages 2130–2137, https://doi.org/10.1093/humrep/dex280 Published: 30 August 2017 STUDY QUESTION What is the likelihood of identifying genetic or endocrine abnormalities in a group of boys with 46, Continue reading…

Validation and application of a novel integrated genetic screening method to a cohort of 1,112 men with idiopathic azoospermia or severe oligozoospermia

Manon S. Oud, Liliana Ramos, Moira K. O’Bryan, Robert I. McLachlan, Özlem Okutman, Stephane Viville, Petra F. de Vries, Dominique F.C.M. Smeets, Dorien Lugtenberg, Jayne Y. Hehir-Kwa, Christian Gilissen, Maartje van de Vorst, Lisenka E.L.M. Vissers, Alexander Hoischen, Aukje M. Meijerink, Kathrin Fleischer, Joris A. Veltman, Michiel J. Noordam First published: 6 September 2017 DOI: Continue reading…

Clinical aspects of infertile 47,XYY patients: a retrospective study

Parnaz Borjian Boroujeni, Marjan Sabbaghian, Ahmad Vosough Dizaji, Shabnam Zarei Moradi, Navid Almadani, Faranak Mohammadpour Lashkari, Mohamad Reza Zamanian & Anahita Mohseni Meybodi Pages 1-6 | Received 06 Sep 2016, Accepted 07 Jun 2017, Published online: 18 Jul 017 http://dx.doi.org/10.1080/14647273.2017.1353143 Abstract 47,XYY syndrome is a sex chromosomal anomaly in men, which may be associated with Continue reading…

Semen quality and pregnancy loss in a contemporary cohort of couples recruited before conception: data from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study

Michael L. Eisenberg, Katherine J. Sapra, Sung Duk Kim, Zhen Chen, Germaine M. Buck Louis Department of Urology, Stanford University, Stanford, California Fertility and Sterlity, October 2017, Volume 108, Issue 4, Pages 613–619 DOI: http://dx.doi.org/10.1016/j.fertnstert.2017.07.008 Objective To study the relationship between semen quality and pregnancy loss in a cohort of couples attempting to conceive. Design Continue reading…

Varicocelectomy to “upgrade” semen quality to allow couples to use less invasive forms of assisted reproductive technology

Mary K. Samplaski, Kirk C. Lo, M.D, Ethan D. Grober, M.D., Armand Zini, M.D., Keith A. Jarvi. Fertility and Sterility, October 2017, Volume 108, Issue 4, Pages 609–612 DOI: http://dx.doi.org/10.1016/j.fertnstert.2017.07.017 Objective To determine the magnitude of improvement in semen parameters after a varicocelectomy and the fraction that have improvements such that couples needing IVF or IUI are Continue reading…

Preclinical evaluation of a TEX101 protein ELISA test for the differential diagnosis of male infertility

 Dimitrios Korbakis, Christina Schiza, Davor Brinc, Antoninus Soosaipillai, Theano D. Karakosta, Christine Légaré, Robert Sullivan, Brendan Mullen, Keith Jarvi, Eleftherios P. Diamandis and Andrei P. Drabovich BMC Medicine201715:60 https://doi.org/10.1186/s12916-017-0817-5© The Author(s). 2017 Received: 28 December 2016Accepted: 13 February 2017Published: 23 March 2017 Background TEX101 is a cell membrane protein exclusively expressed by testicular germ cells Continue reading…

Estimating the effect of immortal-time bias in urological research: a case example of testosterone-replacement therapy

Christopher J.D. Wallis, Refik Saskin, Steven A. Narod, Calvin Law, Girish S. Kulkarni, Arun Seth, Robert K. Nam First published: 18 June 2017 DOI: 10.1111/bju.13918 Objective To quantify the effect of immortal-time bias in an observational study examining the effect of cumulative testosterone exposure on mortality. Patients and Methods We used a population-based matched cohort study of Continue reading…

Safety and effectiveness of collagenase clostridium histolyticum in the treatment of Peyronie’s disease using a new modified shortened protocol

Amr Abdel Raheem, Marco Capece, Odunayo Kalejaiye, Tarek Abdel-Raheem, Marco Falcone, Mark Johnson, Oliver G. Ralph, Giulio Garaffa, Andrew N. Christopher, David J. Ral First published: 14 July 2017 DOI: 10.1111/bju.13932 Abstract Objectives To evaluate the efficacy and safety of collagenase clostridium histolyticum (CCH; Xiapex®, Xiaflex®) in the treatment of Peyronie’s disease (PD) using a Continue reading…

Postoperative Urinary Retention is an Independent Predictor of Short-Term and Long-Term Future Bladder Outlet Procedure in Men

Robert H. Blackwell, Srikanth Vedachalam, Arpeet S. Shah, Anai N. Kothari, Paul C. Kuo, Gopal N. Gupta, Thomas M.T. Turk DOI: http://dx.doi.org/10.1016/j.juro.2017.06.023 Purpose Postoperative urinary retention is a common complication across surgical specialties. To our knowledge no literature to date has examined postoperative urinary retention as a predictor of long-term receipt of surgery for bladder Continue reading…

Evidence of the Impact of Diet, Fluid Intake, Caffeine, Alcohol and Tobacco on Lower Urinary Tract Symptoms: A Systematic Review

Purpose Diet, fluid intake and caffeine, alcohol and tobacco use may have effects on lower urinary tract symptoms. Constructive changes in these modifiable nonurological factors are suggested to improve lower urinary tract symptoms. To better understand the relationship between nonurological factors and lower urinary tract symptoms, we performed a systematic literature review to examine, grade Continue reading…

MP84-09 SYMPTOMS OF DEPRESSION AND SEXUAL DYSFUNCTION

Jack Andrews M.D, Matthew Ziegelmann M.D., Manaf Alom M.B.B.S, Kevin Hebert M.D., Mary E. Westerman M.D. Landon Trost M.D., Rochester, MN DOI: http://dx.doi.org/10.1016/j.juro.2017.02.2650  INTRODUCTION AND OBJECTIVES Patient reported depression is a common data point on sexual health intake surveys. However, limited data are available on correlation between depressive symptoms and sexual dysfunction. We therefore sought to Continue reading…

The importance of genetic parenthood for infertile men and women

S. Hendriks K. Peeraer H. Bos S. Repping E.A.F. Dancet Human Reproduction, Volume 32, Issue 10, 1 October 2017, Pages 2076–2087, https://doi.org/10.1093/humrep/dex256 Published: 23 August 2017 STUDY QUESTION Do men and women beginning to attend a fertility clinic prefer genetic over non-genetic parenthood? SUMMARY ANSWER Nearly, all infertile men and women prefer genetic parenthood. WHAT Continue reading…

Resolution of infertility and number of children: 1386 couples followed for a median of 13 years

A.A. Righarts A. Gray N.P. Dickson L. Parkin W.R. Gillett Human Reproduction, Volume 32, Issue 10, 1 October 2017, Pages 2042–2048, https://doi.org/10.1093/humrep/dex271 Published: 29 August 2017 STUDY QUESTION How common were children among infertile couples? SUMMARY ANSWER A total of 61.7% of infertile couples presenting for care subsequently had live born children 13.1 years after Continue reading…

Effects of Withdrawing α1-Blocker from Combination Therapy with α1-Blocker and 5α-Reductase Inhibitor in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia: A Prospective and Comparative Trial Using Urodynamics

Yoshihisa Matsukawa’Correspondence information about the author Yoshihisa MatsukawaEmail the author Yoshihisa Matsukawa, Shun Takai, Yasuhito Funahashi, Tsuyoshi Majima, Masashi Kato, Tokunori Yamamoto, Momokazu Gotoh Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan DOI: http://dx.doi.org/10.1016/j.juro.2017.05.031 Purpose We compared the effects on lower urinary tract symptoms and bladder outlet obstruction of combination therapy with Continue reading…

The Immediate Management of Pelvic Fracture Urethral Injury—Endoscopic Realignment or Cystostomy?

Qingsong Zou, Shukui Zho, Kaile Zhang, Ranxing Yang, Qiang Fu Department of Urology, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai, China Purpose We determined whether endoscopic realignment or cystostomy would provide the best immediate management of pelvic fracture urethral injury. Materials and Methods We retrospectively reviewed the records of 590 patients with pelvic Continue reading…

Ultrasonographic Assessment of Testicular Viability Using Heterogeneity Levels in Torsed Testicles

Purpose Gross testicular heterogeneity on ultrasound has been associated with testis loss following testicular torsion in children. We aimed to quantify the extent of temporal heterogeneity associated with testis loss in testicular torsion cases using a noninvasive technique to determine a HI (heterogeneity index) on ultrasound images. Materials and Methods We retrospectively studied the records Continue reading…

Biallelic Mutations in CFAP43 and CFAP44 Cause Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella

Sperm motility is vital to human reproduction. Malformations of sperm flagella can cause male infertility. Men with multiple morphological abnormalities of the flagella (MMAF) have abnormal spermatozoa with absent, short, coiled, bent, and/or irregular-caliber flagella, which impair sperm motility. The known human MMAF-associated genes, such as DNAH1, only account for fewer than 45% of affected Continue reading…

The susceptibility of FSHB -211G > T and FSHR G-29A, 919A > G, 2039A > G polymorphisms to men infertility: an association study and meta-analysis

Background Male infertility is a complex disorder caused by genetic, developmental, endocrine, or environmental factors as well as unknown etiology. Polymorphisms in the follicle stimulating hormone beta subunit (FSHB) (rs10835638, c.-211G > T) and follicle stimulating hormone receptor (FSHR) (rs1394205, c.-29G > A; rs6165, c.919A > G; rs6166, c.2039 A > G) genes might disturb Continue reading…

Aberrations of the X chromosome as cause of male infertility

Abstract Male infertility is most commonly caused by spermatogenetic failure, clinically noted as oligo- or azoospermia. Today, in approximately 20% of azoospermic patients, a causal genetic defect can be identified. The most frequent genetic causes of azoospermia (or severe oligozoospermia) are Klinefelter syndrome (47,XXY), structural chromosomal abnormalities and Y-chromosomal microdeletions. Consistently with Ohno’s law, the Continue reading…

Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk for Male Infertility in Asian Population

Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme of folate pathway and required for DNA synthesis and methylation. MTHFE C677T polymorphisms is reported as risk factors for various diseases and disorders like birth defects, metabolic, neurological, psychiatric disorders, and cancers. Several studies have investigated association between the MTHFR C677T polymorphism and male infertility. To assess the Continue reading…

Multicenter study of genetic abnormalities associated with severe oligospermia and non-obstructive azoospermia

Objective * Chong Xie, Xiangfeng Chen, and Yulin Liu contributed equally to this work. Genetic defects are identified in nearly 20% of infertile males. Determining the frequency and types of major genetic abnormalities in severe male infertility helps inform appropriate genetic counseling before assisted reproductive techniques. Methods Cytogenetic results of 912 patients with non-obstructive azoospermia Continue reading…

Racial Variation in Semen Quality at Fertility Evaluation

Objective To identify racial differences in semen quality among men living in the same geographic area and seeking fertility evaluation. Methods Men obtaining a semen analysis for infertility evaluation or treatment between 2012 and 2016 at a single center were identified, and demographic data including height, weight, body mass index (BMI), and age were described. Continue reading…

Chronic prostatitis/chronic pelvic pain syndrome impairs erectile function through increased endothelial dysfunction, oxidative stress, apoptosis, and corporal fibrosis in a rat model

Summary Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is an independent risk factor for the development of erectile dysfunction (ED). But the molecular mechanisms underlying the relationship between CP/CPPS and ED are still unclear. The aim of this study was to investigate the effect of CP/CPPS on erectile function in a rat model and the possible Continue reading…

The role of Cajal cells in chronic prostatitis

Abstract Types of prostatitis can be defined as groups of syndromes in adult men associated with infectious and noninfectious causes characterized frequently by lower abdominal and perineal signs and diverse clinical symptoms and complications. Etiopathogenesis of chronic prostatitis is not well defined. Moreover, its treatment outcomes are not satisfactory. Presence of c-kit positive interstitial cells Continue reading…

Practice Patterns in the Diagnosis and Management of Hypogonadism: A Survey of Sexual Medicine Society of North America Members

Objective To describe practice patterns in the diagnosis and treatment of hypogonadism, as the optimal approaches are controversial. Multiple therapeutic options are currently available for hypogonadal men and treatment patterns vary considerably. The safety of testosterone therapy (TTh) remains understudied. Materials and Methods A 23-question survey regarding diagnosis and treatment of hypogonadism was sent to Continue reading…

Obesity, male infertility, and the sperm epigenome

Obesity is a growing epidemic and a common problem among reproductive-age men that can both cause and exacerbate male-factor infertility by means of endocrine abnormalities, associated comorbidities, and direct effects on the fidelity and throughput of spermatogenesis. Robust epidemiologic, clinical, genetic, epigenetic, and nonhuman animal data support these findings. Recent works in the burgeoning field Continue reading…

The impact of drugs on male fertility: a review

M. Semet, M. Paci, J. Saïas-Magnan, C. Metzler-Guillemain, R. Boissier, H. Lejeune, J.Perrin First published: 16 June 2017Full publication history DOI: 10.1111/andr.12366  Summary Beside cytotoxic drugs, other drugs can impact men’s fertility through various mechanisms. Via the modification of the hypothalamic–pituitary–gonadal axis hormones or by non-hormonal mechanisms, drugs may directly and indirectly induce sexual dysfunction Continue reading…

Gut microbiome and chronic prostatitis/chronic pelvic pain syndrome

 Analysis of the human microbiome continues to reveal new and previously unrealized associations between microbial dysbiosis and disease. Novel approaches to bacterial identification using culture-independent methods allow practitioners to discern the presence of alterations in the taxa and diversity of the microbiome and identify correlations with disease processes. While some of these diseases that have Continue reading…

Chronic prostatitis and its detrimental impact on sperm parameters: a systematic review and meta-analysis

Purpose Prostatitis is a very common urogenital disease of the male with prevalence ranging from 2.2 to 9.7% worldwide. Interestingly, some recent evidences have showed a significant association between chronic prostatitis (CP) and male infertility including a detrimental effect on sperm parameters, reduction of zinc concentration on semen sperm and production of anti-semen antibodies (ASAs). Continue reading…

Sleep disorders in patients with erectile dysfunction

Objective To assess the prevalence of obstructive sleep apnoea (OSA) in men presenting with erectile dysfunction (ED) at a single centre. Patients and Methods All men attending a specialised andrology outpatient department with a new diagnosis of ED were included in this prospective study. All patients completed three questionnaires: the International Index of Erectile Function Continue reading…